Gonadorelin Acetate

What is Gonadorelin Acetate?

• Other Names: Gonadorelin, GnRH, LHRH

• Chemical Nature: Synthetic decapeptide (10 amino acids), identical to natural GnRH

• Primary Function: Stimulates the anterior pituitary to release LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone)

• Form: Usually administered as injection or intravenous infusion

⚙️ Mechanism of Action:

Gonadorelin Acetate binds to GnRH receptors in the anterior pituitary gland, prompting the release of LH and FSH, which regulate the function of the ovaries in females and the testes in males. Unlike long-acting GnRH agonists like Triptorelin or Leuprolide, Gonadorelin is short-acting and mimics the natural pulsatile secretion of GnRH.

🩺 Uses of Gonadorelin Acetate:

✅ 1. Diagnostic Use

• Evaluate Pituitary Function:

  • Used in the GnRH stimulation test to assess whether the pituitary is capable of releasing LH and FSH.

  • Helps diagnose disorders like hypogonadotropic hypogonadism, pituitary failure, or delayed puberty.

✅ 2. Therapeutic Use

• Hypogonadotropic Hypogonadism:

  • In men or women with GnRH deficiency, it may be administered pulsatile (via a pump) to mimic natural hormone rhythms and restore fertility.

• Ovulation Induction:

  • Used in women with amenorrhea or anovulation who want to conceive.

• Cryptorchidism and Delayed Puberty (in boys):

  • May help stimulate testicular descent and initiate puberty.

• Assisted Reproductive Technology (ART):

  • Occasionally used in fertility protocols to stimulate endogenous gonadotropin production.

💉 Dosage and Administration:

• Diagnostic Use:

  • A single IV or SC dose (e.g., 100 mcg), followed by blood draws to measure LH/FSH response at intervals.

• Therapeutic Use:

  • For chronic therapy (e.g., fertility induction), administered pulsatile via infusion pump every 90 minutes over 1–2 weeks or longer.