kisspeptin-10

What is Kisspeptin-10?

• Also Known As: Metastin fragment (kisspeptin-10 is a 10-amino-acid segment)

• Type: Neuropeptide

• Derived From: Kisspeptin (encoded by the KISS1 gene)

• Function: Stimulates the release of GnRH, which then promotes secretion of LH (luteinizing hormone) and FSH (follicle-stimulating hormone)

⚙️ Mechanism of Action:

Kisspeptin binds to the GPR54 receptor (also called KISS1R) on GnRH neurons in the hypothalamus. This triggers the release of GnRH, leading to downstream secretion of LH and FSH from the pituitary gland. These hormones control:

• Ovulation and menstrual cycles in females

• Testosterone production and spermatogenesis in males

It acts as a gatekeeper of puberty and fertility.

🩺 Potential Medical Applications:

✅ 1. Fertility Treatment

• Used in assisted reproductive technology (ART), such as IVF, to trigger ovulation.

• Offers a safer alternative to hCG for inducing ovulation, with lower risk of OHSS (ovarian hyperstimulation syndrome).

✅ 2. Diagnosis of Hypogonadism

• Useful in distinguishing hypothalamic vs pituitary causes of reproductive hormone deficiencies.

✅ 3. Puberty Disorders

• May be used in research or future therapies for delayed puberty or precocious puberty.

✅ 4. Male Infertility

• Potential to stimulate LH/FSH and enhance testosterone production or sperm count in hypogonadal men.